Research Programmes being run in the Department

• Clinical validation of a CYP2B6 pharmacogenetics test based dosing algorithm in the safe and efficacious use of efavirenz in a public health care setting (AIBST-UZCHS GRACE Programme) DPhil

• Drug-drug interaction in the co-administration of the antiretroviral drugs and the antischistosomide praziquantel(AIBST-UZCHS GRACE Programme) DPhil

• Comparison of individualized and standard care for antiviral drug therapy through implementing pharmacogenetics diagnostics(AIBST-UZCHS GRACE Programme) DPhil

• Anti-cancer efficacy of selected herbal plants commonly used to treat cancer in Zimbabwe DPhil

• The effect of genetic polymorphisms on cervical cancer patients under chemoradiotherapy treatment in Harare, Zimbabwe DPhil

• The effects of African potato (hypoxis hemerocallidea) on the pharmacokinetics of tenofovir and lamivudine DPhil

• Genetic basis of validity of warfarin exposure responses in African populations – a pharmacogenetics approach DPhil

• Pharmacokinetics and pharmacogenetics of tamoxifen in healthy volunteers: effect of the CYP2D6*17 on the plasma levels of tamoxifen and its metabolites(AIBST-UZCHS GRACE Programe) MPhil

• Praziquantel metabolism and molecular modeling to address rapid first pass metabolism in the development of a paediatric formulation of praziquantel in the treatment of schistosomiasis(AIBST-UZCHS GRACE Programe)

• HIV-1 Genetic diversity and natural polymorphisms of the integrase gene in integrase inhibitor naïve patients in Zimbabwe MPhil