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Professor Rutendo B.L. Zinyama-Gutsire

Senior Lecturer

Professor Rutendo B.L. Zinyama-Gutsire (Associate Professor)

Diploma of the London School of Hygiene and Tropical Medicine (DLSHTM); BSc Honours Degree in Biological Sciences (UZ); MSC Biotechnology (UZ); MPH (London University, LSHTM); Masters in Clinical Trials (London University, LSHTM); PhD (University of the Witwatersrand, S.A.) 

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Skype: Rutendo Zinyama-Gutsire

 

Publications

  1. HIV-1 Vertical Transmission in Zimbabwe in 622 Mother and Infant Pairs: Rethinking the Contribution of Mannose Binding Lectin Deficiency in Africa. Zinyama-Gutsire RB, Christiansen M, Hedley PL, Rusakaniko S, Hagen C, Stray-Pedersen B, Buzdugan R, Cowan F, Chasela C. OMICS. 2016 Jul;20(7):433-41. doi: 10.1089/omi.2016.0056. Epub 2016 Jun 17.

  2. Practical Approach to Biobanking in Zimbabwe: Establishment of an Inclusive Stakeholder Framework. Matimba A, Tybring G, Chitereka J, Zinyama-Gutsire R, Dandara C, Bürén E, Dhoro M, Masimirembwa C. Biopreserv Biobank. 2016 Oct;14(5):440-446. Epub 2016 Apr 15.

  3. HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency? Rutendo B.L Zinyama-Gutsire, Charles Chasela, Per Kallestrup Simbarashe Rusakaniko, Michael Christiansen, Bernard Ngara, Exnevia Gomo, Henrik Ullum, Christian Erikstrup, Hans O. Madsen Babill Stray-Pedersen, Peter Garred Takafira Mduluza. OMICS: A Journal of Intergartive Biology. 2015. Vol 19, number 9.

  4. Role of Mannose-Binding Lectin Deficiency in HIV-1 and schistosoma Infections in a Rural Adult Population in Zimbabwe. Rutendo B.L Zinyama-Gutsire, Charles Chasela, Hans O. Madsen, Simbarashe Rusakaniko, Per Kallestrup, Michael Christiansen, Exnevia Gomo, Henrik Ullum, Christian Erikstrup, Shungu Munyati, Edith N. Kurewa, Babill Stray-Pedersen, Peter Garred Takafira Mduluza. PLOS One. 2015. 0(4): e0122659 :10.1371/journal.pone.0122659.

  5. HIV and schistosomiasis in rural Zimbabwe: the association of retinol-binding protein with disease progression, inflammation and mortality. Kotzé SR, Zinyama-Gutsire R, Kallestrup P, Benn CS, Gomo E, Gerstoft J, van Dam G, Mortensen OH, Ullum H, Erikstrup C. Int J Infect Dis. 2015 Apr;33:159-64. doi: 10.1016/j.ijid.2015.01.015. Epub 2015 Jan 22.

  6. Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis. Dillon DG, Gurdasani D, Riha J, Ekoru K, Asiki G, Mayanja BN, Levitt NS, Crowther NJ, Nyirenda M, Njelekela M, Ramaiya K, Nyan O, Adewole OO, Anastos K, Azzoni L, Boom WH, Compostella C, Dave JA, Dawood H, Erikstrup C, Fourie CM, Friis H, Kruger A, Idoko JA, Longenecker CT, Mbondi S, Mukaya JE, Mutimura E, Ndhlovu CE, Praygod G, Pefura Yone EW, Pujades-Rodriguez M, Range N, Sani MU, Schutte AE, Sliwa K, Tien PC, Vorster EH, Walsh C, Zinyama R, Mashili F, Sobngwi E, Adebamowo C, Kamali A, Seeley J, Young EH, Smeeth L, Motala AA, Kaleebu P, Sandhu MS; African Partnership for Chronic Disease Research (APCDR). Int J Epidemiol. 2013 Dec;42(6):1754-71. doi: 10.1093/ije/dyt198.

  7. Interpreting and dismissing the relevance of the wait and wipe finding from the circumcision studies conducted in Africa Paul Ndebele, Sithembile Ruzario, Rutendo Zinyama-Gutsire. Malawi Medical Journal. December 2013. 24(5). 113-115.

  8. Polymorphism in the interleukin-7 receptor α gene and mortality in untreated HIV-infected individuals. Hans Hartling, Lise Thorner, Christian Erikstrup, Rutendo Zinyama, Per Kallestrup, Exnevia Gomo, Susanne Nielsen and Henrik Ullum. AIDS. 2013. 1615-1620.

  9. Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection. Jakobsen MR, Cashin K, Roche M, Sterjovski J, Ellett A, Borm K, Flynn J, Erikstrup C, Gouillou M, Gray LR, Saksena NK, Wang B, Purcell DF, Kallestrup P, Zinyama-Gutsire R, Gomo E, Ullum H, Ostergaard L, Lee B, Ramsland PA, Churchill MJ, Gorry PR. PLoS One. 2013 Jun 18;8(6):e65950.

  10. HLA-G3 untraslated region 14-base pair deletion: Association with poor survival in an HIV infected Zimbabwean population. Margit Larsen, Christian Erikstrup, Lise Thorner, Rutendo Zinyama, Per Kallestrup, Exnevia Gomo, Susanne Nielsen, Henrik Ullum et al. 2013. J Infec Dis. 207 : 903-906. 2013.

  11. CCL3 gene copy number and survival in an HIV infected Zimbabwean population. Margit Larsen, Christian Erikstrup, Lise Thorner, Rutendo Zinyama, Per kallestrup, Exnevia Gomo, Susanne Nielsen, Henrik Ullum et al. Infection Genetics and Evolution. 2012. (12) 1087-1093.

  12. Downregulation of MIP-1α/CCL3 with praziquantel treatment in Schistosoma haematobium and HIV-1 co-infected individuals in a rural Zimbabwean community. Zinyama-Gutsire R, Kallestrup P, Ullum H Butterworth A, Erikstrup C , Gomo E Vennervald B.J Mduluza T. BMC Infectious Diseases. 2009. 9: 174-185.

  13. Schistosomiasis and infection with HIV-1 in rural Zimbabwe: systemic Inflammation during Co-infection and after treatment for schistosomiasis. Erikstrup C, Kallestrup P, Zinyama-Gutsire R, Gomo E, Govert J van –Dam, Andre Deelder, Butterworth A, Bente K Pedersen, Sisse R Ostrowski, Jan Gerstoft, Ullum H. Am. J Trop. Med. 2008. 79(3) 331-337.

  14. p24 as a predictor of mortality in a cohort of HIV-1-infected adults in rural Africa. Erikstrup C, Kallestrup P, Zinyama-Gutsire RB, Gomo E, Lüneborg-Nielsen M, Gerstoft J, Schüpbach J, Ullum H, Katzenstein TL. J Acquir Immune Defic Syndr. 2008 Jul 1;48(3):345-9. doi: 10.1097/QAI.0b013e31817dc3d1.

  15. Reduced mortality and CD4 cell loss among carriers of the interleukin 10-1082G allele in a Zimbabwean cohort of HIV-1 infected adults. Erikstrup C, Kallestrup P, Zinyama-Gutsire R, Gomo E, Butterworth A, Bente K Pedersen, Sisse R Ostrowski, Jan Gerstoft, Ullum H. AIDS. 2007. 21: 2283-2291.

  16. Predictors of mortality in a cohort of HIV-1-infected adults in rural Africa. Erikstrup C, Kallestrup P, Zinyama R, Gomo E, Mudenge B, Gerstoft J, Ullum H. J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):478-83.

  17. Schistosomiasis and HIV in rural Zimbabwe: efficacy of treatment of schistosomiasis in individuals with HIV coinfection. Kallestrup P, Zinyama R, Gomo E, Butterworth AE, van Dam GJ, Gerstoft J, Erikstrup C, Ullum H. Clin Infect Dis. 2006 Jun 15;42(12):1781-9.

  18. Schistosomiasis and HIV-1 infection in rural Zimbabwe: implications of coinfection for excretion of eggs. Kallestrup P, Zinyama R, Gomo E, Butterworth AE, van Dam GJ, Erikstrup C, Ullum H. J Infect Dis. 2005 Apr 15;191(8):1311-20.

  19. Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load. Kallestrup P, Zinyama R, Gomo E, Butterworth AE, Mudenge B, van Dam GJ, Gerstoft J, Erikstrup C, Ullum H. J Infect Dis. 2005 Dec 1;192(11):1956-61

  20. HIV in Africa - still a major matter of unsafe sex. Kallestrup P, Zinyama R, Gomo E, Gerstoft J, Ullum H. Int J STD AIDS. 2004 Oct;15(10):709-10

  21. Low prevalence of anti-HCV antibodies in an HIV endemic area of Zimbabwe support sexual transmission as the major route of HIV transmission in Africa. Per Kallestrup, Rutendo Zinyama, Exnevia Gomo, Ebbe Dickmeiss, Per Platz, Jan Gerstoft, Henrik Ullum.. AIDS. 2003. Jun 13;17(9):1400-2.

  22. Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumour necrosis factor-alpha and inteleukin-10. R. Zinyama and L B Sigola. Immunology. December 2001. 104 (4): 439-436.

  23. The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection. Mduluza T, Ndhlovu PD, Madziwa TM, Midzi N, Zinyama R, Turner CM, Chandiwana SK, Nyazema N, Hagan P. Mem Inst Oswaldo Cruz. 2001;96 Suppl:157-64.

  24. Adrenaline inhibits nitric oxide production through beta1 and beta2 adrenergic receptors. L B Sigola and R. Zinyama Immnunology. July 2000. 100 (3): 359-363.

 

Research Interests

My research interests are in Immunology of infectious diseases focusing on HIV, malaria and schistosomiasis and HIV Drug resistance testing. I have over the years co-authored publications on HIV and schistosomiasis immunology. Zimbabwe is one of the country’s worst hit by the HIV epidemic, with huge numbers of people currently on ART and HIV drug resistance is on the increase. It is therefore an urgent need to validate low cow HIV drug resistance testing kits like Oligonucleotide Ligation Assay (OLA) for use as point of care in patient management. Such results are very relevant to our local setting and will be shared with relevant policy makers in the Ministry of Health. Validation of the Oligonucleotide Ligation Assay (OLA) kit, a low-cost HIV drug resistance kit for use in our low resource settings and confirm the results using Sanger and Next Generation Sequencing.

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