Research

Overview

Research is a core function of the University of Zimbabwe. Research is regarded as integrally linked with clinical services, and research areas include development of improved diagnosis, prevention, treatment and advocacy strategies for childhood illness, so advancing the care of children and improving current management. Research activities within the school include many research projects and studies, educational activities around research and mentorship and development of clinician scientists and researchers. All divisions are involved in research. There are many research collaborations with other departments within the CHS, with other departments within the University of Zimbabwe, with other national institutions and with overseas institutions. Much of the research focuses on national health priorities regarding childhood illnesses.

Publications

Recent Publications (2016)

For the year 2016 and as at 18 October 2016, the Department of Paediatrics and Child Health has published 25 Journal articles, 3 journal articles have been accepted for publication and 2 have been submitted and awaiting response (see below):

Journal Article(s)- Published

1. Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy.Prendergast AJ, Szubert AJ, Berejena C, Pimundu G, Pala P, Shonhai A, Musiime V, Bwakura-Dangarembizi M, Poulsom H, Hunter P, Musoke P, Kihembo M, Munderi P, Gibb DM, Spyer M, Walker AS, Klein N; ARROW Trial Team.J Infect Dis. 2016 Jul 15;214(2):226-36. doi: 10.1093/infdis/jiw148. Epub 2016 May 18.
2. Chronic morbidity among older children and adolescents at diagnosis of HIV infection.McHugh G, Rylance J, Mujuru H, Nathoo K, Chonzi P, Dauya E, Bandason T, Simms V, Kranzer K, Ferrand RA.J Acquir Immune Defic Syndr. 2016 May 11. [Epub ahead of print]
3. Tuberculosis incidence is high in HIV-infected African children but is reduced by co-trimoxazole and time on antiretroviral therapy.Crook AM, Turkova A, Musiime V, Bwakura-Dangarembizi M, Bakeera-Kitaka S, Nahirya-Ntege P, Thomason M, Mugyenyi P, Musoke P, Kekitiinwa A, Munderi P, Nathoo K, Prendergast AJ, Walker AS, Gibb DM; ARROW Trial Team.BMC Med. 2016 Mar 23;14:50. doi: 10.1186/s12916-016-0593-7.Ć Page 16
4. Shedding of Oral Poliovirus Vaccine (OPV) by HIV-Infected and -Uninfected Mothers of OPV-Vaccinated Zimbabwean Infants.Holubar M, Troy SB, Nathoo K, Stranix-Chibanda L, Musingwini G, Srinivas N, Huang C, Junn A, Halpern MS, Maldonado YA.J Pediatric Infect Dis Soc. 2016 Jan 12. pii: piv083. [Epub ahead of print]
5. Sustainable HIV treatment in Africa through viral-load-informed differentiated care.Working Group on Modelling of Antiretroviral Therapy Monitoring Strategies in Sub-Saharan Africa, Phillips A, Shroufi A, Vojnov L, Cohn J, Roberts T, Ellman T, Bonner K, Rousseau C, Garnett G, Cambiano V, Nakagawa F, Ford D, Bansi-Matharu L, Miners A, Lundgren JD, Eaton JW, Parkes-Ratanshi R, Katz Z, Maman D, Ford N, Vitoria M, Doherty M, Dowdy D, Nichols B, Murtagh M, Wareham M, Palamountain KM, Chakanyuka Musanhu C, Stevens W, Katzenstein D, Ciaranello A, Barnabas R, Braithwaite RS, Bendavid E, Nathoo KJ, van de Vijver D, Wilson DP, Holmes C, Bershteyn A, Walker S, Raizes E, Jani I, Nelson LJ, Peeling R, Terris-Prestholt F, Murungu J, Mutasa-Apollo T, Hallett TB, Revill P.Nature. 2015 Dec 3;528(7580):S68-76..
6. Chronic lung disease in HIV-infected children established on antiretroviral therapy.Rylance J, Mchugh G, Metcalfe J, Mujuru H, Nathoo K, Wilmore S, Rowland-Jones S, Majonga E, Kranzer K, Ferrand RA.,AIDS. 2016 Sep 20. [Epub ahead of print]
7. Levin MJ, Lindsey JC, Kaplan SS, Schimana W, Lawrence J, McNeal MM, Bwakura-Dangarembizi M, Ogwu A, Mpabalwani EM, Sato P, Siberry G, Nelson M, Hille D, Weinberg GA, Weinberg A. Safety and Immunogenicity of a Live Attenuated Pentavalent Rotavirus Vaccine in HIV-Exposed Infants With or Without HIV Infection in Africa. AIDS DOI: 10.1097/QAD.0000000000001258,2016
8. Prendergast AJ, Bwakura-Dangarembizi M, Mugyenyi P, Lutaakome J; Kekitiinwa A; Thomason MJ, Gibb DM, Walker AS. on behalf of the ARROW Trial Team. Reduced bacterial skin infections in HIV-infected African children randomized to long-term cotrimoxazole prophylaxis. AIDS DOI: 10.1097/QAD.0000000000001264,2016
9. Nyazika TK, Masanganise F, Hagen F, Bwakura-Dangarembizi MF, Ticklay IM, Robertson VJ. Cryptococcal Meningitis Presenting as a Complication in HIV-Infected Children: A Case Series from Sub-Saharan Africa. Pediatr Inf Dis J 2016, May 16
10. Prendergast AJ, Szubert AJ, Berejena C, Pimundu G, Pala P, Shonhai A, Musiime V, Bwakura-Dangarembizi M, Poulsom H, Hunter P, Musoke P, Kihembo M, Munderi P, Gibb DM, Spyer M, Walker AS, and Klein N and the ARROW Trial Team. Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy. Journal of Inf Dis 2016;214: 226-236Ć Page 17
11. Crook AM, Turkova A, Musiime V, Bwakura-Dangarembizi M, Bakeera-Kitaka S, Nahyria-Ntege P, Thomason M, Mugyenyi P, Musoke P, Kekitiinwa A, Munder P, Nathoo K, Prendergast AJ, Walker AS, Gibb DM. Tuberculosis incidence is high in HIV-infected African children but is reduced by co-trimoxazole and time on antiretroviral therapy. BMC 2016
12. Makadzange AT, Higgins-Biddle M, Chimukangara B, Birri R, Gordon M, Mahlanza M, McHugh G, van Dijk JH, Bwakura-Dangarembizi M, Masimirembwa C, Phelps B, Ndungu T, Amzel A, Ojikutu BO, Walker BD, Ndhlovu CE.Clinical, Virologic, Immunologic Outcomes and Emerging HIV Drug Resistance Patterns in Children and Adolescents in Public ART Care in Zimbabwe. Plos One 2015
13. Grace Mashavave, Patience Kuona, Willard Tinago, Babill Stray-Pedersen, Marshall Munjoma and Cuthbert Musarurwa. Dried blood spot omega-3 and omega-6 long chain polyunsaturated fatty acid levels in 7-9 year old Zimbabwean children: A cross sectional study. BMC Clinical Pathology 2016; 16(1): DOI 10.1186/s12907-016-0035-7
14. Cryptococcal Meningitis Presenting as a Complication in HIV-infected Children: A Case Series From Sub-Saharan Africa. Tinashe K Nyazika, Faith Masanganise, Ferry Hagen, Mutsawashe F Bwakura-Dangarembizi, Ismail M H Ticklay, Valerie J Robertson, Pediatr Infect Dis J 2016 Sep;35(9):979-80
15. Safety, Acceptability, and Feasibility of Early Infant Male Circumcision Conducted by Nurse-Midwives Using the AccuCirc Device: Results of a Field Study in Zimbabwe. Webster Mavhu, Natasha Larke, Karin Hatzold, GetrudeNcube, Helen A Weiss, Collin Mangenah, Prosper Chonzi, Owen Mugurungi, Juliet Mufuka, Christopher A Samkange, Gerald Gwinji, Frances M Cowan, Ismail Ticklay Glob Health SciPract 2016 Jul 13;4Suppl 1:S42-54. Epub 2016 Jul 13.
16. Perspectives of Parents and Health Care Workers on Early Infant Male Circumcision Conducted Using Devices: Qualitative Findings From Harare, Zimbabwe. Webster Mavhu, Karin Hatzold, GetrudeNcube, Shamiso Fernando, Collin Mangenah, KumbiraiChatora, Owen Mugurungi, Ismail Ticklay, Frances M Cowan Glob Health SciPract 2016 Jul 13;4Suppl 1:S55-67. Epub 2016 Jul 13.
17. Comparative Cost of Early Infant Male Circumcision by Nurse-Midwives and Doctors in Zimbabwe. Collin Mangenah, Webster Mavhu, Karin Hatzold, Andrea K Biddle, GetrudeNcube, Owen Mugurungi,Ismail Ticklay, Frances M Cowan, Harsha Thirumurthy Glob Health SciPract 2016 Jul 13;4Suppl 1:S68-75. Epub 2016 Jul 13.Ć Page 18
18. HIV Exposed Uninfected Children at School Age: Developing Country Context , l Kandawasvika GQ, Gumbo FZ, Kuona P .. Int J Virol AIDS 2016,,3(2) 3:024 ISSN: 2469-567X
19. Neurocognitive consequences of HIV in preschool age Zimbabwean children: A brief report ,Kandawasvika GQ1, Mapingure PM2, Pazvakavambwa IE1, Stray-Pedersen B3.Journal of HIV and AIDS 2(2) ,2016: doi http: //dx.doi.org/10.16966//2380-5536.122
20. J. Matsekete; Clemence Chidziva; Maureen Wellington; Hilda A Mujuru; Cordelia Kunzekwenyika; Tsitsi Bandason; Sharai Shamu; Rashida A Ferrand; Chris Prescott; Ruedi Luethy. Hearing impairment and deafness among HIV infected children and adolescents in Harare, Zimbabwe. Central African Journal of Medicine Vol 61, No. 9-12 (2015)
21. Rashida Abbas Ferrand, Jamilah Meghj, Khameer Kidia, Ethel Dauya, Tsitsi Bandason, Hilda Mujuru, Getrude Ncube, Stanley Mungofa, Katharina Kranzer. The effectiveness of Routine Opt-out HIV Testing for children in Harare, Zimbabwe. J Acquir Immune Defic Syndr 2016; 71: e24¡Ve29
22. Bandason T, McHugh G, Dauya E, Mungofa S, Munyati SM, Weiss HA, Mujuru H, Kranzer K, Ferrand RA. Validation of a screening algorithm to identify older children and adolescents living with HIV in primary care facilities in high HIV prevalence settings. AIDS 2016, 30:779¡V78
23. Grace McHugh, Jamie Rylance, Hilda Mujuru, Kusum Nathoo, Prosper Chonzi, Ethel Dauya, Tsitsi Bandason, Victoria Simms, Katharina Kranzer, Rashida A Ferrand. Chronic morbidity among older children and adolescents at diagnosis of HIV infection J Acquir Defic Syndr 2016 May 11
24. Raluca Buzdugan, Mi-Suk Kang Dufour, Sandra I Mccoy, Constancia Watadzaushe, Jeffrey Dirawo,Angela Mushavi, Hilda Angela Mujuru, Agnes Mahomva, Rugare Abigail Kangwende, Anna Hakobyan, Owen Mugurungi, Frances M Cowan, Nancy S Padian. Option A Improved HIV-free Infant Survival and Mother to Child HIV Transmission at 9-18 Months in Zimbabwe. AIDS 2016 Jun 19; 30(10) 1652-62
25. Mother to child transmission of Tuberculosis, a problem in Resource Limited Settings under Reported or Undiagnosed-A case report. Gumbo FZ, Kembo c. J Preg Child Health 2016, 3:2